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Pregnant or nursing patients should not use GLP-1 agents and should consult their provider before conception

If you have diabetes and choose to drink, monitor blood sugar closely, eat food with drinks, limit intake strictly, and know how to recognize and treat low blood sugar

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The polyethylene glycolylated mouse leptin antagonist (PEG-MLA)-treated mice exhibit increased fasting and glucose stimulated plasma insulin levels, decreased whole-body insulin sensitivity, elevated hepatic glucose production, and impaired insulin-mediated suppression of hepatic glucose production (Levi et al., The decrease of body fat stores in uncontrolled insulin-deficient diabetes results in marked reduce of plasma leptin levels (German et al., 2009)

GLP-1 analogues are all injectable therapies, which may be a drawback for some patients, although oral semaglutide is in development and was recently approved by the US Food and Drug Administration