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ER is also expressed in the hippocampus, amygdala, and cerebral cortex, where it participates in adult neurogenesis, synaptic plasticity, and new neuron formation (Weiser et al., 2008)

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It is still unclear whether the effect of GLP-1RAs is a result of the direct activation of the hepatic GLP-1 receptor, or an indirect effect caused by weight loss, glycemic control, changes in lipoprotein metabolism, or improved insulin sensitivity [15,34]