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Safety and Efficacy of the New, Oral, Small-Molecule, GLP-1 Receptor Agonists Orforglipron and Danuglipron for the Treatment of Type 2 Diabetes and Obesity: Systematic Review and Meta-Analysis of Randomized Controlled Trials

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There was no significant difference in plasma total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, leptin, adiponectin, resistin or interleukin-6 in Gipr Syn/ mice compared to Gipr fl/fl mice, although plasma tumour necrosis factor (TNF) and monocyte chemoattractant protein-1 (MCP-1) were lower in Gipr Syn/ mice than in Gipr fl/fl mice (Extended Data Fig

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Treatment of NCI-H716 or STC-1 cells with the Ca 2+ ionophore ionomycin or with phorbol myristate acetate (PMA) increases cytosolic Ca 2+ levels and stimulates GLP-1 secretion in a dose-dependent manner [251,253]