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In obese older adults undergoing a hypocaloric diet combined with resistance training, supplementation with whey proteins, leucine, and vitamin D, associated to a protein intake of ~ 1.1 g/kg vs

This endogenous GLP-1 enters the bloodstream, reaches the joint, binds to GLP-1 receptors in joint tissue, and protects cartilage

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Lancet 398 , 143155 (2021)

IIH is driven by an increase in intracranial pressure that can present as severe visual loss to debilitating headaches due to compression of the optic nerve and papilloedema [101]