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Metformin's primary mechanism involves activation of AMP-activated protein kinase (AMPK) in hepatocytes, which suppresses gluconeogenesis and significantly reduces hepatic glucose output

GIP-1 is stimulated by meal intake and glucose-induced hyperosmolarity in the duodenum

Nine months in, I've lost over 50 lbs and started hormone therapy too

Ongoing outcome clinical trials in other groups of patients and more detailed mechanistic studies will shed further light on the mechanisms of cardiovascular benefit with SGLT2 inhibitors

Much of the long-term safety data also comes from early versions of the drugs

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