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In animal studies, GLP-1RA exposure was associated with reduced fetal growth, delayed skeletal ossification, and reductions in maternal weight gain and food consumption (109)

The FDA recommends discontinuing semaglutide at least two months before a planned pregnancy due to the drug's long half-life

m-Ex4: mineralized exenatide particles

however, the effect of tachyphylaxis on gastric emptying (especially with chronic use) remains unclear

Efficacy and safety of GLP-1 receptor agonists, dual agonists, and retatrutide for weight loss in adults
