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Conclusions GLP-1 agonists reduce fetal survival, weight, growth and skeletal ossification and can induce major congenital anomalies

However, their rapid growth also brings major financial challenges for patients and employers

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Additionally, activation of GLP-1R has previously been demonstrated to induce IL-10 expression in chronic pain models [23], supporting the decisive role of GLP-1R in mediating the resolution of inflammation

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Effects of glucagon-like peptide-1 receptor agonists on cardiovascular risk: a meta-analysis of randomized clinical trials