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The authors suggest that therapies aimed at enhancing incretin activity may offer similar benefits in the management of critically ill patients with sepsis, primarily by supporting euglycemia and modulating the hosts inflammatory response (42)
This glucose-dependent action is a critical safety feature: it means GLP-1 therapy does not cause low blood sugar on its own, because the hormone's effect on insulin production automatically shuts off when glucose levels normalize
Jelly Roll added that concerns about possible side effects along with not wanting an asterisk attached to his transformation also factored into his decision

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Therefore, DPP-4 inhibitors are a safe choice for the elderly and those with kidney disease, as they help control diabetes without the risk of causing further harm [7]

doi: 10.1016/j.pnpbp.2020.109872
