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GI side effects affect most users early on but are transient, nausea peaks during dose escalation and fades as your body adapts Semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound) have the highest nausea rates

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If you miss a dose, there are simple rules to follow: If you remember within four days, take the missed dose as soon as possible and then go back to your normal weekly schedule

However, if the overdose was severe or caused significant dehydration or hypoglycemia, your doctor may recommend delaying your next dose by several days or temporarily stepping back to a lower dose before titrating up again