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A robust reduction in BMI was also observed in a case report from Sciacovelli et al [126], who described an 18-year-old male who developed panhypopituitarism and HO after surgical intervention of a CP

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In the SURMOUNT 1 trial, tirzepatide at doses of 5 mg, 10 mg and 15 mg were evaluated against placebo, with pooled tirzepatide groups resulting in significant decreases in total cholesterol, LDL-C, VLDL-C, FFA, and triglycerides and an increase in HDL-C at week 72 of follow-up [35]

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They believed it differed from pancreozymin, another small intestine hormone identified by Ivy in 1928 that was subsequently renamed cholecystokinin (CCK) (Kosaka, Lim)