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[99], which involved transplantations of fecal microbiota obtained from depressed patients into a microbiota-depleted antibiotic rat model, the animals developed depressive-like symptoms, which were manifested by behavioral differences such as decreased sucrose intake in the sucrose preference test, a lower number of entries to an open arm in the elevated plus-maze test, and an increase in a plasma kynurenine/tryptophan ratio

A related formulation, Wegovy (also semaglutide but at higher doses), is separately licensed for weight management

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Should metformin remain the first-line therapy for treatment of type 2 diabetes
doi: 10.1210/jc.2018-01176 70 KanetoHTakamiASprangerRAmanoAWatanabeDNiemoellerE
