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79 , 80 The criteria for increased cardiovascular risk in SURPASS4 were known coronary, peripheral arterial or cerebrovascular disease, or aged 50 years with either history of chronic kidney disease and an estimated glomerular filtration rate of 6000 people with type 2 diabetes, tirzepatide was associated with clinically meaningful reductions in both HbA1c and body weight when used across the diabetes treatment continuum, from monotherapy to combination with basal insulin