glp 1 agonist moa GLP-1 Receptor Agonists as Treatments for Type 2 Diabetes Glucagon-like peptide-1 - Wikipedia

2023, doi: 10.1056/NEJMoa2307563

The effect of GLP-1 depends on blood glucose levels since it can only potentiate glucose-stimulated insulin secretion from islet beta cells in the hyperglycemic state rather than in the normal blood glucose state (95, 96)

In all patients, there was a 44% reduction in risk of colorectal cancer when using GLP-1RAs as compared to insulin, and a 25% reduction in risk as compared to metformin use

Human trials are ongoing, but even modest effects in opioid use disorder could be clinically meaningful given the favorable safety profile of GLP-1 drugs compared with existing treatments

RICORS2040: the need for collaborative research in chronic kidney disease

Sustainable weight loss requires balanced eating habits, regular exercise, and stress management