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Trials showed that starting with a lower dose and gradually increasing it could help minimize gastrointestinal discomfort

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5.15 Anaphylaxis and Angioedema Hypersensitivity reactions, including anaphylaxis and angioedema, have occurred in patients treated with topiramate in the postmarketing setting

Trial data shows mild to moderate gastrointestinal issues such as nausea, vomiting, and diarrheacommon with GLP-1 medications