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Description
Tirzepatide is still legally Lillys alone
Clinical trial data from the STEP program showed that semaglutide 2.4mg weekly produced average weight loss of 14.9% of body weight over 68 weeks, compared to tirzepatide at 15mg which achieved approximately 22.5% in the SURMOUNT trials
Tirzepatide, compared to both GLP-1 and NNC0090-2746, shows biased signaling at GLP-1R, favoring cAMP response over -arrestin recruitment, which leads to low efficacy for GLP-1R internalization (108110)
Which of these medications is best for weight loss
Neuroreport 29 (12), 10461053
I.KoychevI.et al (2025)
