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Therefore, in-depth research into the relationship between energy metabolism abnormalities, dopamine neurotrasmettitorial impairment, and insulin resistance will help us better understand the PD pathogenesis

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Costs can be in the single millions for small molecules compared to mid- to high tens of millions for peptides

Treatment with 30 g/kg AC3174, an exenatide analog, administered via an osmotic pump for 28 days in Lep ob mice on a high trans -fat diet significantly reduced liver weight, hepatic lipid accumulation, and plasma alanine transaminase levels in comparison with pair-fed, weight-matched controls (30)

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BBB penetration of GLP-1 agonsits has also been tested in several studies using mice