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However, the review also makes an important point: the cause has not been established

When taken together, you may experience orthostatic hypotension. This is the clinical term for a sudden drop in blood pressure when you stand up quickly from a sitting or lying position

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In the PIONEER 6 trial, involving patients with T2D and high CV risk (including established CVD, chronic kidney disease, or age 50 years with risk factors), oral semaglutide demonstrated non-inferiority for MACE (HR 0.79