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The general recommendation for a sample size to assess the safety of a weight-reduction drug is 3,000 subjects randomized to the investigational drug within the to-be258 recommended dosage range and no fewer than 1,500 subjects randomized to placebo for at least 1 year of treatment at the maintenance dosage Multiple #obesitytrials have successfully used flexible dosing regimens

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Hypothyroidism slows metabolism and makes weight loss harder, but GLP-1 receptor agonists like semaglutide can still be effective when thyroid hormone is optimized

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