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Conclusions Consistent with clinical trials, real-world tirzepatide treatment was associated with greater 6-month weight reduction and more frequent achievement of weight-reduction targets and improvements in select cardiometabolic parameters than semaglutide among adults with obesity without diabetes

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42.8% being treated with insulin at baseline)

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Widely used for type 2 diabetes mellitus and obesity, GLP-1RAs may increase risk for injection-site reactions.

Tirzepatide reduces hunger signals, but overeating is still possible