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In some cases, a lower-dose approach may be appropriate

For these individuals, GLP-1 drugs can be truly transformative, said Dr

High blood glucose levels or glucose fluctuations can lead to vascular endothelial dysfunction and atherosclerosis through mechanisms such as increased oxidative stress, the formation of advanced glycation end products (AGEs), and the activation of protein kinase C (PKC) (Section 5.2 Prospective Clinical Trial Progress and Results of Tirzepatide in the Treatment of Type 2 Diabetes with Cardiovascular Disease for details)

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Jackson Miller is a board-certified medicine physician & hospitalist

Islet GLP-1 production is also mediated by the cytokine IL-6, which is released in response to exercise, obesity and diabetes [163,164]