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This is the second time the FDA has rejected SPN-830

Glucagon-Like Peptide (GLP)-1(9-36)Amide-Mediated Cytoprotection Is Blocked by Exendin(9-39) Yet Does Not Require the Known GLP-1 Receptor
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Also, the combination of GLP-1RA with cholecystokinin (CCK) and fibroblast growth factor 21 (FGF21) has been studied in preclinical settings (93, 94)

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