glp 1 agonist pharmacology glp-1_analogs [TUSOM Discovery of GLP-1–Based Drugs for

[87] found that chronic liraglutide treatment improved nitric oxide (NO)-mediated vasodilation in both the coronary arteries and microcirculation, partially normalizing myocardial remodeling independent of body weight or blood glucose changes

In particular, at a dosage of 2.4 mg per week, it has been shown to induce an average weight loss between 9.6% and 17.4%, as well as a reduction in waist circumference and arterial hypertension and an improvement of lipid profile [34,35,36,37,39]

76 EX-BID demonstrated superior outcomes compared to insulin glargine in liver-related indicators such as LFC, FIB-4 index, and liver enzymes, as well as metabolic indicators like post-prandial glucose and LDL-C

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These drugs fall within two categories: human GLP-1 backbone agents (that is, albiglutide, dulaglutide, liraglutide and semaglutide) and exendin-4 backbone agents (that is, exenatide, lixisenatide and tirzepatidethe latter activating both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors) 1

In our experience, transitioning directly to subcutaneous semaglutide 1 mg once weekly from another GLP-1 receptor agonist can be associated with nausea or GI disturbance