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GIP receptor activation enhances insulin secretion in a glucose-dependent manner and, based on preclinical and early clinical data, may improve insulin sensitivity in adipose tissue

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This suggests the possibility that some native polyphenols, while being active, may be of greater benefit to the body after undergoing some degree of microbiome-mediated metabolism

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Nutrients that Stimulate GLP-1 Secretion (also known as secretagogues) GLP-1 is produced in L cells which are abundant in the lining of the large intestine (Figure 3)

While these medications are not FDA-approved, they provide flexibility and are prescribed by licensed healthcare providers when standard formulations or doses are unsuitable