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The Importance of Maintaining Muscle Mass with GLP-1 Use GLP-1 medications work best when paired with a complete lifestyle strategy

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The effects of exendin-4 on reward were also diminished by pretreatment with the estrogen receptor--selective antagonist, suggesting that signaling via the estrogen receptor- specifically is necessary for GLP-1R analog's reward-reducing effects (40)

Support for fat loss: Mounjaro helps the body preferentially lose fat mass, helping to preserve muscle during weight loss

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People taking the once-daily pill were largely able to keep off the weight they originally lost taking a different GLP-1 injectable