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Emerging research suggests allulose may stimulate modest increases in GLP-1 hormone release through the intestinal L-cells, but the magnitude of this effect remains far smaller than therapeutic GLP-1 medications

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Thus, activating GLP-1R could also reduce histone lactylation by inhibiting the expression of p300

Through activation of receptors such as FFAR2 and FFAR3, SCFAs directly influence GLP-1 secretion and insulin sensitivity

doi: 10.1016/0167-0115(94)90204-6

As an example, Black women living in more socially disadvantaged neighborhoods had significantly worse breast cancer survival compared to those living in the least disadvantaged neighborhoods, even after accounting for clinical and individual socioeconomic factors (23)