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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Bendotti G, Montefusco L, Lunati ME, Usuelli V, Pastore I, Lazzaroni E, Assi E, Seelam AJ, El Essawy B, Jang J, Loretelli C, D'Addio F, Berra C, Ben Nasr M, Zuccotti G, Fiorina P
Sources Jiang Y, et al
Some researchers reach a point where tirzepatide stops producing results even at maximum doses
When one health system compared more than a thousand bariatric-surgery patients with about two thousand people on semaglutide or tirzepatide, surgery caused more total weight loss and more absolute muscle loss, but the share that came off as lean stayed in the same modest range for both (2026 cohort)
The best time to consider surgery is when you have reached your goal weight and been stable for 2-3 months or more
Accessed 3 Nov 2025
