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The result is pronounced postprandial and fasting blood glucose reduction, delayed gastric emptying (transient), reduced hunger, enhanced satiety, and decreased caloric intake

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That matters because repeated injections in the same spot can cause lipohypertrophy, a thickened or lumpy area under the skin that may alter absorption

Why GLP-1 Side Effects Focus on the Digestive System GLP-1 receptors are concentrated in the gastrointestinal tract, pancreas, and brain regions controlling appetite and satiety