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### Funding Statement SDL and AC were supported by the National Science Foundation (Grant Nos.\ CAREER DMS-1944574 and DMS-2325258) ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained

For example semaglutide lowered proteins that are upregulated in fibromyalgia, hypertension, substance use disorders, neuropathic pain, osteoarthritis, psoriasis, depression, asthma, breast cancer and reduced ejection fraction, and increased proteins that are downregulated in these conditions." And maybe some cancer : "(plus chronic lymphocytic leukemia and small lymphocytic lymphoma although q value0.05)" This following quote is a HUGE validation of proteomics in drug studies - great outcome for patients, drug companies, and of course proteomics tools companies: "Taken together, these clinical trial data of semaglutide pharmacotherapy for body weight reduction showcase the broad opportunities afforded by proteomic analyses, including offering insights into mechanisms of action and potential novel indications to be tested in clinical studies