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Aggregated S in turn reciprocally worsens mitochondrial stress and sirtuin loss, locking the system into a degenerative cycle that culminates in dopaminergic neuronal loss

Whether the spectacular preclinical pharmacology of GLP-1R/GcgR co-agonists will translate through successful phase 3 registration trials is a question that will be answered in the coming years, but the pursuit of multifunctional, targeted therapeutics is destined to continue
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