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Both GLP-1 receptor agonists and metformin are commonly used to manage insulin resistance , but they work in different ways

doi: 10.1152/ajpregu.00092.2002, 39 FlegalK

Unlike weekly injectable GLP-1s, where a missed dose still provides several days of drug exposure, missing a daily orforglipron dose creates a full day without therapeutic drug levels

However, researchers began to notice that these drugs were also effective in suppressing appetite, helping promote weight loss

[DOI] [PMC free article] [PubMed] [Google Scholar] 136.Light PE, Manning Fox JE, Riedel MJ, Wheeler MB

Tirzepatide body aches tend to be transient and manageable with adequate hydration, electrolyte supplementation, and gentle movement