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3.3 Mitochondrial dysfunction and oxidative stress Chronic hyperglycemia in patients with T2DM leads to peripheral insulin resistance, whereas impaired insulin signaling pathways in the brains of patients with AD lead to brain insulin resistance, both of which are closely related to mitochondrial dysfunction and OS (Zhang et al., 2023)

(65) demonstrated that intraperitoneal rather than intravenous administration, which more accurately mimics the endogenous route of action of GLP-1, requires intact vagal afferent fibers to induce satiation
Imaging techniques in alzheimers disease: A review of applications in early diagnosis and longitudinal monitoring

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Early GLP-1 RAs (exenatide) [archived link] and exenatide ER [archived link]) were designed after a GLP-1 version found in Gila monster venom [archived link]
