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The active pharmaceutical ingredientsemaglutide or tirzepatideis the same chemical compound, just prepared under compounding pharmacy regulations instead of bulk pharmaceutical manufacture

Lancet Diabetes Endocrinol (2019) 7(10):77685

Following failure of initial treatment with metformin and comprehensive lifestyle interventions, the American Diabetes Association (ADA)/European Association for the Study of Diabetes (EASD) consensus report and ADA Standards of Care for Diabetes recommend GLP1RAs for use throughout the treatment pathway for T2D, in particular if there is concern about hypoglycaemia or weight gain

Managing the distance between public enthusiasm and clinical evidence has become part of the consultation itself

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WashU Medicines findings also showed a decreased risk of neurocognitive disorders such as Alzheimers and dementia