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(2) Select the genetic variants that were robustly associated with the expression level of GLP-1R/GIPR/GCGR from Genotype-Tissue Expression (GTEx) [27] and Gene expression quantitative trait loci (eQTLGen) consortium [28] and glycated hemoglobin A1c (HbA1c) from Neale Lab ( N = 344,182, in each tissue (Single mr 0.75), which means there are distinct variants influencing gene expression and HbA1c levels separately within the gene region, were deemed as potentially alternative variants