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For reference, retatrutide titration in these trials followed a slow ramp over 2436 weeks: Weeks 14: 2mg/week Weeks 58: 4mg/week Weeks 912: 8mg/week Week 13+: 12mg/week (for 12mg group) The slow titration is important GI tolerability at higher doses improves significantly with gradual escalation

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Non-pharmacological approaches including rest, cold compresses applied to the forehead or neck, relaxation techniques, and stress management may provide additional relief