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Retrieved March 10, 2026, from 20 Newman, E

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How GLP-1s work in the body GLP-1 receptor agonists mimic GLP-1 (short for glucagon-like peptide-1), a gut hormone that your body naturally releases when you eat

Weekly monitoring during escalation: During dose increases, measure resting heart rate each morning using the same protocol

However, statistical mediation analyses from trials such as SELECT suggest that only a portion of the MACE reduction is explained by weight loss alone, pointing to direct, weight-independent vascular and cardiac benefits [12,66]

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