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Despite the link, the role of insulin abnormalities in PD remains contentious, with little difference found between patients with PD and healthy controls in peripheral insulin resistance, quantified using a hyperinsulinemic-euglycemic clamp [71]

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All participants were T2DM patients being treated with a combination of metformin, sodium-glucose co-transporter-2, or sulfonylurea

The role of proopiomelanocortin (POMC) neurones in feeding behaviour
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