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Dose titration schedule Clinicians typically start patients at a lower dose (0.8 mg) and gradually increase it over several weeks or months

Implications for obesity care & access The approval adds to the rapidly expanding landscape of GLP-1-based therapies for obesity, where injectables have dominated clinical practice and significantly shifted treatment paradigms

The growing epidemic of diabetes mellitus

Across all GLP-1 medications, 12-month persistence (still taking the medication at one year) ranges from 38% to 56% depending on the study and population (Wilding et al., Diabetes Obes Metab 2023)

Weight changes during the first month at a starting dose are variable

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