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Futile cycling of glucose has also been suggested to confer glucagons energy expenditure effects, whereby glucagon stimulates opposing pathways of hepatic glucose production and consumption (56)

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The anorexigenic and weight-lowering effects of liraglutide are blunted upon genetic ablation of GLP-1R in glutamatergic neurons, yet fully preserved when GLP-1R is deleted in GABAergic neurons [718]

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