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Activation of GPR41 increases the secretion of intestinal peptide YY (PYY) and decreases the secretion of glucose-dependent insulin-releasing polypeptide (GIP) and growth hormone-releasing peptide, thereby reducing glucose uptake (Hu et al., 2018)

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The researchers also found that the benefits of GLP-1 therapy were especially pronounced in older adults, women, and certain racial subgroups

We assess: BMI 30, or 27 with a comorbidity Full medical history Current prescriptions & labs 2

Ideally, the medication would also target the underlying cause of Parkinsons disease

GLP-1 Receptor Agonists Drug-Drug Interaction Table At a glance Primary DDI mechanism / delayed gastric emptying reduces Cmax of co-administered oral drugs Highest-risk combination / insulin or sulfonylureas plus any GLP-1 RA increases hypoglycemia 2- to 3-fold Warfarin / case reports of INR elevation