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[DOI] [PMC free article] [PubMed] [Google Scholar] 39

J., Stefanski, A., et al

They often pop up during dose changes or when appetite shifts

Users on tirzepatide lose an average of 15-22.5% of body weight versus 10-15% on semaglutide at comparable durations

Seek urgent medical help if you experience: severe or persistent abdominal pain (especially if it does not improve or becomes intense) upper abdominal pain that spreads to the back ongoing or uncontrollable vomiting that prevents eating or drinking right-sided abdominal pain , particularly after meals, which may indicate gallbladder problems signs of acute kidney injury such as very low urine output, dark urine, or extreme fatigue allergic reactions including swelling of the face, lips, tongue, or throat, difficulty breathing, or a widespread rash Severe stomach pain Severe stomach pain requires urgent medical attention

Rash A small percentage of trial participants developed skin rashes, typically presenting as small red patches or bumps