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Gastrointestinal side effects The most frequently reported side effects associated with retatrutide treatment are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation
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Recommendations are based on a larger quantity of evidence

Orlistat is indicated for patients with a BMI 30 kg/m 2 or 28 kg/m 2 in association with other risk factors (e.g., hypertension, diabetes, hyperlipidaemia) [10]
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Science 336 , 1262 (2012)
