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As different classes of drugs target different aspects of T2DM via distinct mechanisms of action, a combination of treatments is generally more effective at maintaining glycaemic control than monotherapy over the long term [12]

Taking only partial amounts of semaglutide by counting clicks of an injection pen raises risks of inconsistent doses, leading to side effects or reduced efficacy

[DOI] [PubMed] [Google Scholar] Skibicka, K

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Biomarker endpoints also vary, some focusing on amyloid and tau changes, others on FDG-PET metabolic flux or MRI volumetrics [66]
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