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Subsequently, Moore proposed the hypothesis that intestinal secretions might have a glycemic-lowering effect in diabetics, which was the first study to suggest an effect of intestinal secretions on blood glucose (Perley and Kipnis, 1967)

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To validate this effect in mice, we performed hyperinsulinemic-euglycemic clamps in Dpp4 +/+ (wild-type, WT) and Dpp4 / (global Dpp4 deletion) mice fed a high-fat, high-cholesterol (HFHC) diet for 12 weeks

Preclinical studies suggested that GLP-1RAs reduced immune cell activity and oxidative stress in kidney and led to decrease in fibrosis [15, 45]

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