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After a follow-up of 27 months, the researchers reported that just over half of patients (54%) discontinued their prescription for at least 135 days

Brain Res 1732:146673 Moustafa PE, Abdelkader NF, El Awdan SA, El-Shabrawy OA, Zaki HF (2018) Liraglutide ameliorated peripheral neuropathy in diabetic rats: Involvement of oxidative stress, inflammation and extracellular matrix remodeling

Additionally, the appetite suppression that makes these medications effective for weight management may inadvertently reduce overall fluid intake, as patients often consume less food and beverages throughout the day

A research review of 28 trials and 23,000 patients showed that tirzepatide produces slightly more weight loss than semaglutide compared to a placebo

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While some studies have shown that chromium supplementation can reduce A1C levels in people with type 2 diabetes, it showed no effect on fasting blood glucose or lipid levels