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In models of compulsive overeating and food addiction, GLP-1RAs consistently decrease binge-like intake of high-fat/high-sugar foods, suppress operant responding for sucrose, and reduce cue-potentiated feeding behaviors [12]
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doi: 10.1371/journal.pone.0193473
However, many prescribers continue phentermine beyond 12 weeks off-label for patients who respond well, do not develop side effects, and have no cardiovascular contraindications
It's worth noting that GLP-1 receptor agonists generally have similar gastrointestinal side-effect profiles, though individual tolerance can vary between agents
Notably, the extracellular perineuronal net surrounding ARC neurons undergoes remodeling in metabolic dysfunction [58]
