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Figure 4 shows the results of SURPASS-4 by tirzepatide dose as well as for all doses pooled, compared to insulin glargine treatment

Once-weekly subcutaneous amycretin up to 60 mg for 36 weeks

Gupta S, Pandak WM, Hylemon PB

At the same time, the data imply that a medicinal chemistry campaign focusing on engineering pharmacokinetically optimized GLP-1MK-801 conjugates might give rise to drugs that could outperform the current incretin-based treatments for obesity, such as semaglutide and tirzepatide

During treatment, GLP-1RAs show a neutral risk compared with DPP4is and a lower risk compared with SGLT2is
