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Columns report design, treatment/control arms, sex, age, BMI, and key inclusion/exclusion criteria, frequently operationalized with diagnostic codes Abbreviations: GLP1 RA Glucagonlike peptide-1 receptor agonist, IIH idiopathic intracranial hypertension, BMI body mass index, SD standard deviation, IQR interquartile range, ICP intracranial pressure, ICD10/ICD10CM International Classification of Diseases, 10th Revision/Clinical Modification, ATC A10BJ (ATC code for GLP1 RAs), UCWM usual care weight management, ER emergency room, DPP4 dipeptidyl peptidase4, RCT randomized controlled trial All studies included patients diagnosed with IIH

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HEK293T cells (obtained from and certified by the Cell Bank at the Chinese Academy of Sciences and confirmed as negative for mycoplasma contamination) were cultured in DMEM supplemented with 10% (v/v) foetal bovine serum, 50 IU mL 1 penicillin and 50 g mL 1 streptomycin

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When to Seek Medical Help: While nausea is common with GLP-1 medications, it should be manageable

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