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doi: 10.18632/oncotarget.3958 41 KarkeniEMorinSOBou TayehBGoubardAJosselinECastellanoRet al

The enhanced GI effects may cause temporary water weight shifts, while the stronger appetite suppression can lead to reduced food intake that shows up as an artificially steep drop on the scale

Most weight-management programs are built for a completely different stage of life

Because the medication significantly suppresses appetite and slows gastric emptying, many patients find it difficult to eat more than a few hundred calories a day in the beginning

Because retatrutide is not yet approved for general prescribing in the UK, all dosing information must be treated as trial-protocol specific

Preclinical data provides mechanistic support
