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Cases 12 (9), 17121713

The Food and Drug Administration (FDA) has approved Eli Lillys once-daily oral GLP-1 receptor agonist, orforglipron, for adults with obesity, or overweight with weight-related medical problems

Louwagie, MD, PhD, of the Department of Internal Medicine at LewisGale Hospital Montgomery in Blacksburg, Va

The development of these drugs has been based on our evolving understanding of type 2 diabetes and obesity

When traveling, use a portable cooler pack or insulated medication case designed for injectable biologicsthese maintain the 36F46F range for 24 to 48 hours

These medications carry a boxed warning regarding thyroid C-cell tumor risk observed in rodent studies and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)