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Enrolment of female participants is capped at approximately 70% to ensure sufficient male representation, given that participants typically seeking enrolment in obesity trials have been disproportionately female

Private prescribing of unlicensed medicines is legally permissible in the UK under specific circumstances for example, under the MHRA's Early Access to Medicines Scheme (EAMS) or on a named-patient basis but requires clear clinical justification, informed patient consent, and compliance with MHRA guidance on unlicensed medicines

Online clinics like Shed offer access to prescription medications such as Wegovy and Zepbound

Finally, competing risks were not formally addressed

95% CI, 0.72 1.11